RASCL: Rapid Assessment of Selection in CLades through molecular sequence analysisArticle Published on 2022-11-022022-11-16 Journal: PLoS ONE [Category] SARS, 변종, 치료기술, [키워드] acting Analysis assessment automatically COVID-19 pandemic dataset datasets detect evaluate Evolution Genome Genome sequences genomes genomic include Intensive Lineage lineages molecular Mutation natural selection Notation object pathogen Phylogenetic Rapid SARS-CoV-2 selected Selection selective sensitivity sequence Sequence analysis sequencing error Surveillance underlie unmet need variants of concern whole genes yielding [DOI] 10.1371/journal.pone.0275623 PMC 바로가기
Crystallographic study, biological assessment and POM/Docking studies of pyrazoles-sulfonamide hybrids (PSH): Identification of a combined Antibacterial/Antiviral pharmacophore sites leading to in-silico screening the anti-Covid-19 activityResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] acting activities addition Antimicrobial/Antioxidant bioactivity antioxidant Antiviral approach Bioavailability bioinformatics Compound compounds Delta derivative docking result docking study enzyme evaluated exhibited Free radicals identification Identification of the pharmacophore sites in vitro in-silico information Interaction microorganisms mutants NMR omicron Osiris pathogenic microorganism Petra Petra/Osiris/Molinspiration (POM) analyses pharmacophores PROTECT provided pyrazole Pyrazole Linked Sulfonamide Conjugates shown Structure synergistic target protein tested Toxicity X-ray diffraction [DOI] 10.1016/j.molstruc.2022.133605 [Article Type] Research article
Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targetsArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 3CL pro 3CLpro acting antiviral activity approach approach binding binding free energy complex COVID-19 dimeric docked complexes docking explained FDA-approved drug FIVE heterodimeric Host in vitro activity inhibit inhibitor inhibitory activity Ivermectin MD simulation molecular molecular docking Molecular dynamics simulation molecular dynamics simulation. molecular mechanism nuclear previous study protease Proteins reached Replication responsible SARS-CoV-2 SARS-CoV-2 replication shown Structural analysis structural property target translocation variety virus with COVID-19 [DOI] 10.1080/07391102.2021.1911857 PMC 바로가기
Randomized, Double-Blind, Placebo-Controlled Trial of a Throat Spray with Selected Lactobacilli in COVID-19 OutpatientsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] acting acute respiratory syndrome added Administered administration Amplicon sequencing analyses Analysis antibody Antiviral antiviral property antiviral strategy applied Bacteria benefit Care chills collected Combined coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients detectable Diagnosis diarrhea double-blind dried blood spot eligible evaluated Fever Health hospital Hospitalization infected with SARS-CoV-2 Lactobacillaceae lactobacilli Microbiome modulation multifactorial nasopharyngeal viral load nose-throat swab online questionnaire Outpatient Pain Patient per-protocol analysis Placebo placebo-controlled trial positive potential mechanism practitioners qPCR quantitative PCR Randomized reduce reducing reported reported symptom respiratory tract infection respiratory viral disease SARS-CoV-2 selected sequence severity significantly spray strain Symptom symptom resolution the patient the placebo group therapy Throat throat spray. Treatment Trial trials upper respiratory tract Vaccines variant Viral diseases viral infection Viral load was performed [DOI] 10.1128/spectrum.01682-22 PMC 바로가기
Broad-Spectrum Extracellular Antiviral Properties of Cucurbit[ n]urilsArticle Published on 2022-10-142022-11-15 Journal: ACS Infectious Diseases [Category] COVID19(2023년), SARS, 치료제, [키워드] acting amino acids Antiviral Antiviral compound Antiviral effect antivirals Cell Compound compounds Contact cucurbituril disease dose−response Efficacy Extracellular herpes simplex homologue Interaction investigated macrocycle mechanism morbidity Mortality nontoxic pathogen property Protein respiratory syncytial virus responsible RSV SARS-CoV-2 viral surface virucidal virus viruses virustatic. [DOI] 10.1021/acsinfecdis.2c00186 PMC 바로가기
Artificial Intelligence and Deep Learning Assisted Rapid Diagnosis of COVID-19 from Chest Radiographical Images: A SurveyArticle Published on 2022-10-122022-11-15 Journal: Contrast media & molecular imaging [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy acting Analysis applied artificial Asymptomatic Chest Chest CT Community complex COVID-19 COVID-19 pandemic CT scan deep detect Diagnosis domain early stage Effects Elsevier examined intelligence learning machine learning MOST outcome pandemic predict problems provide Rapid Research researcher selected survey symptomatic symptomatic case [DOI] 10.1155/2022/1306664 PMC 바로가기
Deep learning and machine learning-based voice analysis for the detection of COVID-19: A proposal and comparison of architecturesResearch article Published on 2022-10-012022-10-05 Journal: Knowledge-Based Systems [Category] 바이오마커, 진단, 치료기술, [키워드] 1EVowel /e/ vocal task 2SSentence vocal task 3CCough vocal task Accuracy acting AdaBoost adopted Algorithms Analysis applied approach binary Biomarker Biomarkers CFSCorrelation-based Feature Selection Classifier clinically CNN CNNConvolutional neural network collected Convolutional neural network Correlation-based Feature Selection Cough vocal task COVID COVID-19 COVID-19 pandemic COVID-19 positive subjects deep deep learning DLDeep Learning Effect evaluated feature Features forest Healthy control subjects HHealthy control subjects highlight identify independent individual machine learning Mel-frequency Cepstral Coefficients MFCCMel-frequency Cepstral Coefficients MLmachine learning nasal swab NSNasal Swab PCRPolymerase Chain Reaction-based molecular swabs Polymerase Chain Reaction-based molecular swabs positive Positive subjects Positive versus Healthy subjects comparison PPositive subjects PvsHPositive versus Healthy subjects comparison Random forest real time Receiver-Operating Curve Recovered subjects Recovered versus Healthy subjects comparison Rectified Linear Unit ReLuRectified Linear Unit RFRandom Forest ROCReceiver-Operating Curve RRecovered subjects RvsHRecovered versus Healthy subjects comparison selection process Sentence vocal task subject subjects subset support vector machine SVMSupport vector machine Vowel /e/ vocal task [DOI] 10.1016/j.knosys.2022.109539 [Article Type] Research article
Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulationsArticle Published on 2022-10-012022-11-15 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] absence acting acute respiratory syndrome Amino acid Analysis Anti-viral binding site catalytic coronavirus disease Coronavirus-2 COVID-19 distribution docking score effective Entry inhibitor glycoprotein host cell in silico inhibitor Interaction less Ligand MD simulation MD simulations medications metabolism molecular molecular docking nucleic acid offered performed Precision research finding residue SARS CoV-2 spike spike glycoprotein spike glycoprotein. stability starting point target Toxicity viral entry Virtual screening [DOI] 10.1007/s11030-022-10394-9 PMC 바로가기
Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virionsArticle Published on 2022-09-192022-11-15 Journal: PLoS Pathogens [Category] SARS, 치료제, [키워드] 6-Thioguanine ACE2-expressing cells acting antiviral activity antiviral drug antivirals approach betacoronavirus betacoronaviruses biochemical Cell complementary coronavirus demonstrated early stage ectopic expression Effect full-length Genetic GTPase had no HCoV-OC43 HPRT1 in vitro infect Infection inhibit inhibitor lentivirus nucleotide oligosaccharide outcome progeny virion Protein pseudotyped pseudovirus Replication SARS-CoV-2 selective shown spike structural proteins subgenomic RNA target Treatment Viral diseases viral genomes Virus-like particle VLPs yielding [DOI] 10.1371/journal.ppat.1010832 PMC 바로가기
Australian public health COVID-19 messaging is missing its mark in some vulnerable communities and people who reject COVID-19 safety adviceObservational Study Published on 2022-09-032022-10-05 Journal: Journal of Global Health [Category] 임상, [키워드] acting approach Asylum Behavioural intention Care categories Community COVID-19 cross-sectional Deaf defined demographic characteristics Demographic variables examined Express Factor greater group groups Health Impact information investigated less public health public health measure public health messaging recruited respond response Sex Spread Torres Strait [DOI] 10.7189/jogh.12.05037 PMC 바로가기 [Article Type] Observational Study